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Related Experiment Video

Updated: Aug 14, 2025

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
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Depression and cognitive sequelae after a traumatic brain lesion.

Trine Okkerstrøm Ryttersgaard1,2, Jens Østergaard Riis3, Søren Paaske Johnsen2,4

  • 1Department of Neurology, Aalborg University Hospital.

Danish Medical Journal
|January 11, 2023
PubMed
Summary

Rehabilitation significantly improved functional outcomes for young traumatic brain injury (TBI) survivors. Addressing depression and cognitive issues is crucial for better recovery and return to work or school after TBI.

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Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Psychiatry

Background:

  • Acquired brain injury (ABI) significantly impacts young individuals.
  • The Danish Ministry of Health initiated a national study in 2012 to enhance rehabilitation for young ABI survivors.

Purpose of the Study:

  • To investigate changes in depression, cognition, global functional outcome, and return to work/school among young traumatic brain injury (TBI) survivors.
  • To assess the effectiveness of rehabilitation interventions.

Main Methods:

  • An observational one-year follow-up study utilizing data from the Danish registry for young adults with acquired brain injury.
  • Key measures included the Major Depression Inventory, neuropsychological tests, and the Glasgow Outcome Scale - extended (GOS-E).

Main Results:

  • Global functional outcome significantly improved after one year (p = 0.0007).
  • Prevalence of depression decreased from 14.5% to 10.5%, and cognitive sequelae decreased from 31.6% to 19.7%.
  • Depression and cognitive sequelae were associated with lower functional outcomes (p = 0.0016) and reduced return to work/school (p = 0.045).

Conclusions:

  • Emotional and cognitive rehabilitation are vital for young TBI survivors.
  • Addressing depression and cognitive deficits improves global functional outcomes and facilitates return to work/school.