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Corrected T1 Mapping in Children and Young Adults With Autoimmune Liver Disease: Correlation With Histology
Andrew T Trout1,2, Amy E Taylor2, Jennifer L Kasten3
1Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229.
Abstract:
The purpose of this study was to assess relationships between liver-corrected T1 (cT1) values (adjusted for T2* effect, MRI system manufacturer, and field strength) and histologic inflammation and fibrosis in 35 participants (15 women and girls, 20 boys and men; median age, 16.0 years) with autoimmune liver disease. At multivariable analysis, inflammation score (β = 15.5) and sex (β = 56.0 [female]) were independent predictors of cT1, and fibrosis score (β = 32.3) and age (β = 5.5) were independent predictors of cT1 IQR. Liver T1 may have relevance for assessing liver inflammatory activity and fibrosis stage.

