Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pigmentation01:19

Pigmentation

2.5K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.5K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

2.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.0K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.0K
Skin Cancer01:30

Skin Cancer

4.4K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.4K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

5.4K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.4K
Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

1.5K
Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Severe hidradenitis suppurativa exacerbation in temporal association with PD-1 blockade in cutaneous squamous cell carcinoma.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Features of Skin of Color.

Deutsches Arzteblatt international·2026
Same author

A STAT1/ETC/GBP1 axis represents a potential therapeutic target for noncommunicable granulomatous skin disease.

Science advances·2026
Same author

Familial hidradenitis suppurativa is associated with an increased prevalence of metabolic and cardiovascular comorbidity.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8<sup>+</sup> T-cell response.

Cellular & molecular immunology·2026
Same author

Delphi consensus: First-line use of biologics and small molecules in hidradenitis suppurativa.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026

Related Experiment Video

Updated: Aug 14, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.3K

[Physiologic hyperpigmentation on darker skin].

Andreas Glauner1, Esther von Stebut2

  • 1Klinik und Poliklinik für Dermatologie und Venerologie, Uniklinik Köln, Medizinische Fakultät, Universität zu Köln, Kerpener Str. 62, 50935, Köln, Deutschland.

Dermatologie (Heidelberg, Germany)
|January 11, 2023
PubMed
Summary
This summary is machine-generated.

Recognizing normal variations in skin of color, like hyperpigmentation, is crucial for accurate diagnosis and patient care. This guide helps physicians differentiate common skin findings from pathology in diverse populations.

Keywords:
Circumscribed dermal melanocytosisDemarkation linesMelanonychia striataMucosal hyperpigmentationReference standards

More Related Videos

Quantification of Hypopigmentation Activity In Vitro
06:08

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

11.4K
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

993

Related Experiment Videos

Last Updated: Aug 14, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.3K
Quantification of Hypopigmentation Activity In Vitro
06:08

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

11.4K
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
03:47

Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application

Published on: September 27, 2024

993

Area of Science:

  • Dermatology
  • Dermatopathology
  • Aesthetic Medicine

Context:

  • Increasingly diverse patient populations necessitate accurate identification of skin of color variations.
  • Normal skin variations are often misdiagnosed as pathological conditions.
  • Physiological changes in skin of color require specific clinical recognition.

Purpose:

  • To describe common hyperpigmentation variations in dark skin.
  • To aid clinicians in classifying these phenomena.
  • To reduce misdiagnosis of normal skin variations as pathology.

Summary:

  • Discusses common hyperpigmentation in dark skin, including demarcation lines, mucosal hyperpigmentation, melanonychia striata, and circumscribed dermal melanocytosis.
  • Highlights the importance of recognizing normal physiological variations.
  • Aims to improve diagnostic accuracy and patient counseling.

Impact:

  • Facilitates accurate clinical classification of skin of color variations.
  • Enhances physician confidence in managing diverse patient skin concerns.
  • Optimizes resource allocation by reducing unnecessary investigations for benign conditions.