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Related Concept Videos

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Drug Administration and Therapy Phases: Overview

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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
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Antiepileptic Drugs: Potassium Channel Activators01:20

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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
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Phase II reactions are essential for the detoxification and elimination of drugs from the body. These reactions involve the conjugation of parent drugs or their phase I metabolites with endogenous molecules, resulting in more hydrophilic drug conjugates. The primary conjugation reactions in this phase are sulfation and glucuronidation. Both sulfation and glucuronidation typically produce biologically inactive metabolites. However, in some cases involving prodrugs, active metabolites may be...
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Related Experiment Video

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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Rezvilutamide: First Approval.

Susan J Keam1

  • 1Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. dru@adis.com.

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|January 11, 2023
PubMed
Summary

Rezvilutamide is a new oral prostate cancer drug approved in China. This second-generation androgen receptor antagonist treats metastatic hormone-sensitive prostate cancer with high tumor burden.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Prostate cancer remains a significant global health challenge.
  • Androgen receptor antagonists are a cornerstone of prostate cancer therapy.
  • Metastatic hormone-sensitive prostate cancer (mHSPC) requires effective treatment options.

Purpose of the Study:

  • To summarize the key development milestones of rezvilutamide.
  • To highlight the regulatory approval of rezvilutamide in China.

Main Methods:

  • Review of preclinical and clinical development data for rezvilutamide.
  • Analysis of regulatory submission and approval process in China.

Main Results:

  • Rezvilutamide, an oral second-generation androgen receptor antagonist, has been developed.

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  • In June 2022, rezvilutamide received approval in China for mHSPC patients with high tumor burden.

    • Conclusions:

    • Rezvilutamide represents a significant advancement in the treatment of prostate cancer.
    • The approval marks a key milestone in making rezvilutamide available to patients.