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Related Experiment Video

Updated: Aug 14, 2025

Biofunctionalization of Magnetic Nanomaterials
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Bimodal brush-functionalized nanoparticles selective to receptor surface density.

Huu Trong Phan1, Dominic Lauzon2, Alexis Vallée-Bélisle2

  • 1Faculty of Pharmacy, University of Montreal, Montreal H3C 3J7, QC, Canada.

Proceedings of the National Academy of Sciences of the United States of America
|January 11, 2023
PubMed
Summary

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This summary is machine-generated.

Functionalizing nanoparticles with bimodal polymer monolayers enhances selective cell targeting. Longer protective chains on these nanoparticles significantly improve selectivity for pathological cells overexpressing receptors.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Surface Chemistry

Background:

  • Targeted drug delivery relies on nanoparticles selectively binding to cells with high receptor density.
  • Bimodal polymer monolayers (BM) on nanoparticles are theoretically proposed to enhance this selectivity.
  • Experimental validation of BM-functionalized nanoparticle selectivity under controlled conditions is lacking.

Purpose of the Study:

  • To experimentally demonstrate and quantify the enhanced selectivity of BM-functionalized nanoparticles for target cells.
  • To investigate the impact of protective chain length and molar ratio in BM on nanoparticle selectivity.
  • To develop a theoretical model supporting the observed selectivity mechanisms.

Main Methods:

  • Utilizing surface chemistry to create well-defined platforms mimicking the nanoparticle-cell interface.
Keywords:
bimodal brushfunctionalizationnanoparticlereceptor surface densityselectivity

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  • Employing surface plasmon resonance (SPR) and atomic force microscopy (AFM) to assess nanoparticle adsorption.
  • Developing a theoretical model for protective brush repulsion and integrating it with super-selectivity theory.

    • Main Results:

    • BM-functionalized nanoparticles exhibited selective adsorption to surfaces mimicking target cells.
    • Enhanced selectivity was observed with longer protective chains in the bimodal polymer monolayer.
    • A theoretical model confirmed that a steric energy barrier, requiring numerous ligand-receptor bonds, drives selectivity.

    Conclusions:

    • The relative length and molar ratio of polymer chains in BM can be tuned for targeted receptor density.
    • This study provides experimental proof and a theoretical framework for designing BM-functionalized nanoparticles for selective cell targeting.
    • Findings lay the groundwork for rational design of nanoparticles for pathological condition targeting.