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The effect of probiotics on immune responses and their therapeutic application: A new treatment option for multiple

Behnam Hashemi1, Maryam Abdollahi1, Sanaz Abbaspour-Aghdam2

  • 1Department of Bacteriology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 11, 2023
PubMed

Insights

Probiotics show promise in managing multiple sclerosis (MS) by positively influencing the gut microbiome, immune cells, and inflammatory cytokines. This review suggests probiotics can aid in the recovery and control of MS in both human and animal studies.

Area of Science:

  • Neuroimmunology
  • Microbiome research
  • Gastroenterology

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory disease impacting the central nervous system, characterized by nerve demyelination.
  • The precise etiology of MS remains elusive, yet immune system modulation and targeted anti-inflammatory strategies show therapeutic potential.
  • Emerging research highlights the gut microbiome's influence on immune function and inflammatory processes, particularly in the context of MS.

Purpose of the Study:

  • To investigate the therapeutic effects of probiotics on immune cells and inflammatory cytokines in patients with multiple sclerosis (MS).
  • To explore the potential mechanisms through which probiotics may influence the immune system and inflammatory pathways relevant to MS.
  • To review existing evidence on the efficacy of probiotics in managing MS in both human and animal models.

Main Methods:

  • Systematic review of existing literature on probiotics and their impact on immune markers in MS.
  • Analysis of studies examining the modulation of gut microbiota composition by probiotics.
  • Evaluation of research focusing on the effects of probiotics on immune cell populations and inflammatory cytokine profiles.

Main Results:

  • Probiotics demonstrate a beneficial effect on immune cell modulation and inflammatory cytokine levels in individuals with MS.
  • Alterations in the gut microbiome induced by probiotics appear to influence systemic immune responses relevant to MS.
  • Evidence from human and animal studies suggests probiotics can contribute to the recovery and management of MS.

Conclusions:

  • Probiotics represent a promising adjunctive therapy for multiple sclerosis (MS) by modulating immune responses and inflammation.
  • Targeting the gut microbiome with probiotics may offer a novel strategy for improving disease outcomes in MS patients.
  • Further research is warranted to elucidate the precise mechanisms and optimize probiotic interventions for MS management.
Keywords:
Chronic inflammatory diseaseMicrobiotaMultiple sclerosisProbiotics

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