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Related Concept Videos

Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Maintenance of the ES Cell State01:14

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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Stem cell biology needs a theory.

Ben D MacArthur1

  • 1Alan Turing Institute, London, UK; Mathematical Sciences, University of Southampton, Southampton, UK; Faculty of Medicine, University of Southampton, Southampton, UK.

Stem Cell Reports
|January 11, 2023
PubMed
Summary
This summary is machine-generated.

Computational models aid stem cell research, but defining a "good" model remains challenging. This commentary advocates for integrating experimental and theoretical approaches to improve stem cell research quality.

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Area of Science:

  • Stem cell biology
  • Computational modeling
  • Scientific methodology

Background:

  • Computational models are increasingly vital for analyzing stem cell data.
  • A lack of clear criteria for evaluating model quality exists in the field.

Purpose of the Study:

  • To advocate for enhanced integration of experimental and theoretical work in stem cell biology.
  • To propose guidelines for developing high-quality computational models.

Main Methods:

  • This is a commentary, not an empirical study.
  • It synthesizes existing knowledge and proposes a framework.

Main Results:

  • The commentary argues for a more rigorous approach to computational modeling in stem cell research.
  • It outlines principles for establishing robust theoretical frameworks.

Conclusions:

  • Closer integration of experiment and theory is essential for advancing stem cell research.
  • Adopting proposed guidelines will enhance the reliability and interpretability of computational models.