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A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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VEGFR endocytosis: Implications for angiogenesis.

Queen Saikia1, Hannah Reeve1, Areej Alzahrani1

  • 1School of Molecular & Cellular Biology, University of Leeds, Leeds, United Kingdom.

Progress in Molecular Biology and Translational Science
|January 11, 2023
PubMed
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Vascular Endothelial Growth Factor Receptor (VEGFR) endocytosis regulates blood vessel formation. Understanding VEGFR signaling dynamics offers therapeutic potential for diseases linked to abnormal angiogenesis.

Keywords:
Blood vesselEndothelial cellReceptor tyrosine kinaseVascular endothelial growth factor

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Vascular Endothelial Growth Factor (VEGF) superfamily binding to VEGF receptor tyrosine kinases (VEGFRs) and co-receptors is crucial for blood and lymphatic vessel formation.
  • Dysfunctional VEGF signaling is implicated in pathological angiogenesis, a hallmark of cancer and inflammatory diseases.
  • Endocytosis of VEGFRs typically attenuates signaling and promotes endothelial cell quiescence.

Purpose of the Study:

  • To explore the dynamic relationship between VEGFR endocytosis, intracellular signaling, and protein turnover.
  • To elucidate the implications of VEGFR endocytosis and intracellular signaling on angiogenesis.
  • To highlight the therapeutic potential of understanding VEGFR dynamics in human diseases.

Main Methods:

  • Review of current literature on VEGFR endocytosis and signaling.
  • Analysis of studies investigating VEGFR trafficking and intracellular signalosomes.
  • Examination of the role of endosomal VEGFR signaling in angiogenesis.

Main Results:

  • Activated VEGFRs can sustain signaling from intracellular compartments like endosomes, challenging the traditional view of signal attenuation upon endocytosis.
  • VEGFR endocytosis, signaling, and turnover are intricately linked, influencing angiogenic processes.
  • Intracellular VEGFR signaling contributes to the complex regulation of angiogenesis.

Conclusions:

  • The understanding of VEGFR dynamics, including endocytosis and intracellular signaling, is critical for comprehending angiogenesis.
  • Targeting VEGFR endocytosis and intracellular signaling pathways presents a promising therapeutic strategy for diseases characterized by aberrant angiogenesis.
  • Further research into VEGFR intracellular trafficking and signaling holds significant potential for developing novel treatments for various human pathologies.