Related Experiment Video

Updated: Aug 14, 2025

Conducting Respiratory Oscillometry in an Outpatient Setting
14:49

Conducting Respiratory Oscillometry in an Outpatient Setting

Published on: April 8, 2022

7.3K

Respiratory comorbidities in severe asthma: focus on the pediatric age

Amelia Licari1,2, Beatrice Andrenacci1, Maria Elisa Di Cicco3

  • 1Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.

Expert Review of Respiratory Medicine
|January 11, 2023
PubMed

Insights

Asthma comorbidities significantly impact outcomes, affecting control and quality of life. Managing these treatable traits is crucial for severe pediatric asthma, yet their specific effects remain understudied.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Clinical Immunology

Background:

  • Comorbidities in asthma frequently lead to adverse outcomes, including poor disease control, exacerbations, diminished quality of life, and increased healthcare utilization.
  • These comorbidities are recognized as treatable traits, and their effective management is key to achieving optimal asthma control.
  • Despite their prevalence in individuals with asthma, comorbidities can be misdiagnosed, leading to undertreatment or overtreatment, particularly in severe pediatric asthma where their impact is less understood.

Purpose of the Study:

  • To provide a comprehensive, 5-year updated review of respiratory comorbidities in severe asthma.
  • To focus on the epidemiology, pathogenesis, and current and future therapeutic strategies for these comorbidities.

Main Methods:

  • A systematic review of literature published within the last five years.
  • Focus on respiratory comorbidities in the context of severe asthma, with a specific emphasis on pediatric populations.

Main Results:

  • Respiratory comorbidities present unique challenges in childhood asthma management.
  • Multidisciplinary, age-specific, and integrated management approaches are essential.
  • Further research is needed to elucidate the interrelations, synergistic effects, and long-term impacts of these comorbidities.

Conclusions:

  • Understanding and managing respiratory comorbidities is vital for improving outcomes in severe pediatric asthma.
  • Longitudinal studies are necessary to explore treatable risk factors, therapeutic effectiveness, and the link between comorbidities and lung function trajectories.
Abstract

Keywords:
Asthma comorbiditiesbreathing pattern disordersbronchiectasisinducible laryngeal obstructionsobstructive sleep apneapediatricsrhinitisrhinosinusitissevere asthmasevere asthma with fungal sensitization

More Related Videos

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.0K
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.0K

Related Concept Videos

Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
889
Common Respiratory Disorders01:31

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
782
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.6K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
504
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.8K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.6K