Related Experiment Video
Updated: Aug 14, 2025
07:03
Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
999
Metabolic Dysfunction-Associated Fatty Liver Disease and Mortality: A Population-Based Cohort Study
Kyung-Soo Kim1, Sangmo Hong2, Hong-Yup Ahn3
1Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
Diabetes & Metabolism Journal
|January 12, 2023
Summary
Metabolic dysfunction-associated fatty liver disease (MAFLD) is linked to increased all-cause and cardiovascular mortality. Identifying MAFLD can help pinpoint individuals at higher risk for these adverse outcomes.
Area of Science:
- Cardiology
- Hepatology
- Public Health
Background:
- Metabolic dysfunction-associated fatty liver disease (MAFLD) is a growing concern.
- The association between MAFLD and mortality risk requires further investigation.
Purpose of the Study:
- To investigate the association between MAFLD and all-cause and cardiovascular mortality.
- To identify high-risk groups for mortality based on MAFLD criteria.
Main Methods:
- A large-scale health examination cohort (394,835 subjects) was analyzed.
- Participants were categorized into normal, NAFLD only, MAFLD only, and combined NAFLD/MAFLD groups.
- Cox proportional hazards models were used to assess mortality risk.
Main Results:
- MAFLD was associated with higher all-cause and cardiovascular death rates.
- Patients with MAFLD only showed elevated mortality risk, though statistical significance varied with adjustments.
- More metabolic dysfunction components increased cardiovascular death risk, particularly in women for all-cause death.
Conclusions:
- MAFLD criteria effectively identify individuals at elevated risk for all-cause and cardiovascular death.
- The presence and severity of metabolic dysfunction are key factors in mortality risk stratification.
More Related Videos
Related Concept Videos
01:24Overview of Lipid Metabolism
2.1K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
2.1K
01:28Overview of Fatty Acid Metabolism
31.0K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
31.0K