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ATPase family AAA domain-containing protein 2 (ATAD2): From an epigenetic modulator to cancer therapeutic target

Jiahui Fu1,2, Jin Zhang3, Xiya Chen1,3

  • 1School of Pharmaceutical Sciences, Shenzhen Technology University, Shenzhen, 518118, China.

Theranostics
|January 12, 2023
PubMed

Insights

ATPase family AAA domain-containing protein 2 (ATAD2) is an emerging oncogene involved in epigenetic modifications and cancer. This review highlights ATAD2

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Oncology

Background:

  • ATPase family AAA domain-containing protein 2 (ATAD2) is an emerging oncogene implicated in human cancers.
  • ATAD2 functions as a transcriptional coactivator involved in epigenetic modifications.
  • Its role in regulating oncogenes and tumor suppressors is linked to enhancer of zeste homologue 2 (EZH2).

Purpose of the Study:

  • To review the structural features and biological functions of ATAD2.
  • To discuss ATAD2's role as an epigenetic modulator and a cancer therapeutic target.
  • To summarize small-molecule inhibitors targeting ATAD2 for improved cancer therapy.

Main Methods:

  • Literature review summarizing existing research on ATAD2.
  • Analysis of ATAD2's structural domains (AAA+ ATPase and bromine domains).
  • Discussion of identified small-molecule inhibitors (e.g., GSK8814, AZ13824374).

Main Results:

  • ATAD2's structure makes it a viable therapeutic target in cancer.
  • Several small-molecule inhibitors targeting ATAD2 have been identified.
  • ATAD2's function as an epigenetic modulator is crucial in cancer development.

Conclusions:

  • ATAD2 is a promising druggable target for cancer therapy.
  • Targeting ATAD2 with small-molecule inhibitors could lead to novel anticancer drugs.
  • Further research into ATAD2 inhibitors may improve potential cancer treatments.
Keywords:
ATPase family AAA domain-containing protein 2 (ATAD2)Anticancer drugCancer therapyEpigenetic modificationSmall-molecule inhibitorTherapeutic target

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