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Cancer Stem Cells and Tumor Maintenance02:40

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Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
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Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

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Targeting Breast Cancer Stem Cells.

Lu Zhang1, Wenmin Chen2,3, Suling Liu1,4

  • 1Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences; State Key Laboratory of Genetic Engineering; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; The Shanghai paracrine Key Laboratory of Medical Epigenetics; Shanghai Key Laboratory of Radiation Oncology; The International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology; Shanghai Medical College; Fudan University, Shanghai 200032, China.

International Journal of Biological Sciences
|January 12, 2023
PubMed
Summary
This summary is machine-generated.

Breast cancer stem cells (BCSCs) drive tumor growth and treatment resistance. This review explores BCSCs, their regulation by the tumor microenvironment, and novel therapies targeting these cells for improved outcomes.

Keywords:
Breast cancer stem cellEpithelial-Mesenchymal TransitionTherapeutic strategiesTumor microenvironment

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Area of Science:

  • Oncology
  • Cancer Biology
  • Stem Cell Research

Background:

  • Breast cancer stem cells (BCSCs) are implicated in tumor initiation, recurrence, and therapeutic resistance.
  • Their self-renewal and differentiation capacities contribute to poor clinical outcomes.
  • Potential origins include genetic mutations, somatic cell dedifferentiation, and epithelial-mesenchymal transition (EMT).

Purpose of the Study:

  • To review the key features of breast cancer stem cells.
  • To highlight factors and the tumor microenvironment regulating BCSC stemness.
  • To discuss emerging therapies targeting BCSCs.

Main Methods:

  • Literature review focusing on breast cancer stem cell biology.
  • Analysis of factors influencing BCSC self-renewal and differentiation.
  • Examination of current and developing BCSC-targeting therapeutic strategies.

Main Results:

  • BCSCs possess significant self-renewal and differentiation potential, leading to poor prognosis.
  • The tumor microenvironment, including cellular and cytokine components, actively modulates BCSC behavior.
  • Various targeted therapies, including small molecules, antibodies, and CAR-T cells, are in clinical trials.

Conclusions:

  • Understanding BCSC biology is crucial for overcoming therapeutic challenges in breast cancer.
  • Targeting the tumor microenvironment's influence on BCSCs offers promising therapeutic avenues.
  • Combination therapies involving novel BCSC-targeting agents show potential for improved patient outcomes.