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Related Experiment Video

Updated: Aug 14, 2025

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

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Spatial orientation - a stable marker for vascular cognitive impairment?

Ellen Lowry¹, Gillian Coughlan², Sol Morrissey¹

¹Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, United Kingdom.

Cerebral Circulation - Cognition and Behavior

|January 12, 2023

Summary

Spatial orientation deficits are a stable marker for vascular cognitive impairment (VCI), a common dementia. Novel tests reveal deficits missed by standard screening, suggesting a new diagnostic tool for VCI.

Keywords:

COT, Clock Orientation Test Egocentric orientation SHQ, Sea Hero Quest Spatial navigation VST, Virtual Supermarket Test Vascular cognitive impairment Vascular dementia Vascular dementia case report WMH, white matter hyperintensities

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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Area of Science:

Neuroscience
Cognitive Psychology
Neurology

Background:

Vascular cognitive impairment (VCI) is the second leading cause of dementia, with limited understanding of early detection markers.
Spatial navigation deficits are recognized in Alzheimer's disease, but their role in VCI requires further investigation.
This study focuses on a unique case of VCI with an identified egocentric orientation deficit.

Observation:

A patient with VCI, initially diagnosed with an egocentric orientation deficit, was re-evaluated three years later.
Spatial navigation tasks and MRI brain scans were utilized to assess persistent spatial deficits.
Conventional screening tools indicated patient recovery, contrasting with specialized spatial testing.

Findings:

The patient consistently demonstrated persistent spatial orientation deficits, sensitive to novel spatial tests.
Diffusion Tensor Imaging (DTI) analysis showed a non-significant trend of reduced structural integrity in posterior SLF tracts.
The medial temporal lobe, crucial for spatial navigation, remained unaffected, suggesting alternative neural pathways involved in VCI.

Implications:

Spatial orientation deficits may serve as a sensitive cognitive marker for early detection of VCI.
These findings highlight the potential of specialized spatial tests to identify subtle cognitive changes missed by standard assessments.
Understanding VCI-specific spatial deficits can inform the development of targeted diagnostic and therapeutic strategies.