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Preparation of Amines: Reductive Amination of Aldehydes and Ketones

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Carbonyl compounds and primary amines undergo reductive amination first to produce imines, followed by secondary amines in the same reaction mixture, using selective reducing agents like sodium cyanoborohydride or sodium triacetoxyborohydride. Reductive amination produces different degrees of substitution of amines depending on the starting amine substrate.

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A Diamine-Oriented Biorefinery Concept Using Ammonia and Raney Ni as a Multifaceted Catalyst.

Xianyuan Wu¹, Mario De Bruyn², Katalin Barta^1,2

¹University of Groningen Stratingh Institute for Chemistry Groningen The Netherlands.

Chemie-Ingenieur-Technik

|January 12, 2023

Summary

This summary is machine-generated.

Lignocellulose can be converted into valuable diamines using Raney Nickel. This process efficiently transforms diols derived from biomass into diamines through hydrogenation and hydrogen-borrowing reactions.

Keywords:

Amine Catalysis Cellulose Lignin

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Area of Science:

Biomass Valorization
Green Chemistry
Catalysis

Background:

Diamines are crucial industrial chemicals with diverse applications.
Sustainable sourcing of chemical feedstocks is an ongoing challenge.
Lignocellulose represents an abundant and renewable biomass resource.

Purpose of the Study:

To investigate the feasibility of utilizing lignocellulose as a feedstock for producing diols.
To develop efficient methods for converting these lignocellulose-derived diols into diamines.
To explore the catalytic role of Raney Nickel in these biomass conversion processes.

Main Methods:

Raney Nickel-catalyzed hydrogenation and demethoxylation for diol formation from lignocellulose components.
Raney Nickel-catalyzed hydrogen-borrowing diamination of diols in the presence of ammonia (NH3).
Analysis of reaction yields and product purity for both diol and diamine formation.

Main Results:

Demonstrated the feasibility of converting lignocellulose into diol-containing molecules.
Achieved good to excellent yields for the transformation of diols into diamines.
Raney Nickel effectively facilitated both diol formation (via hydrogenation/demethoxylation) and diamine formation (via hydrogen-borrowing).

Conclusions:

Lignocellulose is a viable and sustainable source for producing diols.
The developed method offers an efficient route to synthesize diamines from biomass-derived diols.
Raney Nickel is a key catalyst enabling these valuable chemical transformations from renewable resources.