Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Capillary Electrophoresis: Instrumentation01:20

Capillary Electrophoresis: Instrumentation

301
Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...
301

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics.

Nature physics·2025
Same author

Rheology and Microstructural Behavior of Semidilute Suspensions of Semiflexible Rods across Five Decades of Shear Rate.

Macromolecules·2025
Same author

Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms.

Advanced healthcare materials·2025
Same author

Poiseuille and extensional flow small-angle scattering for developing structure-rheology relationships in soft matter systems.

Current opinion in colloid & interface science·2024
Same author

Flow Activation Energy of High-Concentration Monoclonal Antibody Solutions and Protein-Protein Interactions Influenced by NaCl and Sucrose.

Molecular pharmaceutics·2024
Same author

Microfluidic techniques for mechanical measurements of biological samples.

Biophysics reviews·2024
Same journal

Gelation behavior of polysaccharide-based interpenetrating polymer network (IPN) hydrogels.

Rheologica acta·2026
Same journal

Fully angularly resolved 3D microrheology with optical tweezers.

Rheologica acta·2024
Same journal

Rheological design of thickened alcohol-based hand rubs.

Rheologica acta·2022
Same journal

Exploring the gelation of aqueous cellulose nanocrystals (CNCs)-hydroxyethyl cellulose (HEC) mixtures.

Rheologica acta·2021
Same journal

Elucidating the rheological implications of adding particles in blood.

Rheologica acta·2021
Same journal

Characterizing the dynamic rheology in the pericellular region by human mesenchymal stem cell re-engineering in PEG-peptide hydrogel scaffolds.

Rheologica acta·2020
See all related articles

Related Experiment Video

Updated: Aug 14, 2025

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer
08:47

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer

Published on: April 21, 2022

3.5K

A small-volume microcapillary rheometer.

Paul F Salipante1, Steve Kuei1, Steven D Hudson1

  • 1Polymers and Complex Fluids Group, National Institute of Standards and Technology, 100 Bureau Dr., Gaithersburg, MD 20899, USA.

Rheologica Acta
|January 12, 2023
PubMed
Summary
This summary is machine-generated.

This study presents a new capillary device for precise viscosity measurements of small liquid volumes. The microfluidic rheometer enables accurate analysis of shear rate-dependent viscosity for microliter samples, with full recovery.

Keywords:
Capillary rheometerFlow trackingMicroflow

More Related Videos

Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions
11:38

Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions

Published on: April 19, 2018

8.0K
Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix
09:13

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

Published on: July 10, 2020

3.2K

Related Experiment Videos

Last Updated: Aug 14, 2025

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer
08:47

Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer

Published on: April 21, 2022

3.5K
Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions
11:38

Combining Microfluidics and Microrheology to Determine Rheological Properties of Soft Matter during Repeated Phase Transitions

Published on: April 19, 2018

8.0K
Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix
09:13

Macro-Rheology Characterization of Gill Raker Mucus in the Silver Carp, Hypophthalmichthys molitrix

Published on: July 10, 2020

3.2K

Area of Science:

  • Fluid Mechanics
  • Materials Science
  • Analytical Chemistry

Background:

  • Accurate viscosity measurement is crucial for characterizing fluids.
  • Traditional rheometers often require large sample volumes, limiting analysis of precious or limited samples.
  • Microfluidic approaches offer potential for reduced sample consumption.

Purpose of the Study:

  • To develop and validate a capillary device for measuring shear rate-dependent viscosity of microliter-scale liquid volumes.
  • To enable precise rheological characterization using minimal sample amounts.
  • To demonstrate the utility of the device for both Newtonian and non-Newtonian fluids.

Main Methods:

  • A pneumatic system drives microliter liquid samples through a microcapillary into a larger glass capillary.
  • An optical linear sensor tracks the air-liquid meniscus in real-time.
  • Flow direction reversal is controlled by a pneumatic valve, enabling repeated measurements.
  • Volumetric flow rate and pressure drop are used to calculate viscosity as a function of shear rate.

Main Results:

  • The device accurately measures shear rate-dependent viscosity over 2-3 decades of shear rate (10 to 10^5 s^-1) using at least 50 microL of sample.
  • Viscosity measurements for Newtonian and non-Newtonian fluids (1-100 mPa s) validated against reference methods.
  • The sample is essentially fully recovered after measurement.
  • The operational range and sources of uncertainty (instrumentation, meniscus, inertial effects) were analyzed.

Conclusions:

  • The developed capillary device offers a sensitive and efficient method for microvolume rheology.
  • Its ability to measure and recover small sample volumes makes it ideal for applications with limited or valuable materials.
  • This microfluidic rheometer provides a valuable tool for precise fluid characterization in various scientific disciplines.