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Effect of interleukin-17 on periodontitis development: An instrumental variable analysis
Sebastian-Edgar Baumeister1, Birte Holtfreter2, Stefan Lars Reckelkamm1
1Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany.
Journal of Periodontology
|January 12, 2023
Summary
Interleukin-17 (IL-17) may protect against periodontitis. This study used genetic analysis to investigate IL-17
Area of Science:
- Immunology
- Genetics
- Oral Health
Background:
- Elevated interleukin-17 (IL-17) levels correlate with periodontitis severity.
- The causal role of IL-17 in periodontitis development remains unclear.
Purpose of the Study:
- To investigate the causal effect of IL-17 on periodontitis using genetic instrumental variable analysis.
Main Methods:
- Utilized 12 genetic variants from a genome-wide association study (GWAS) as instrumental variables for IL-17.
- Linked these variants to a large GWAS dataset of periodontitis cases and controls.
- Employed generalized weighted least squares analysis, accounting for linkage disequilibrium.
Main Results:
- A significant inverse association was observed between genetically proxied IL-17 and periodontitis (OR, 0.84; P = 0.003).
- Results remained consistent after sensitivity analyses for horizontal pleiotropy.
Conclusions:
- Findings suggest that IL-17 may have a protective effect against the development of periodontitis.
- Further research is warranted to elucidate the precise mechanisms of IL-17 in periodontal health.
