Related Experiment Video
Updated: Aug 14, 2025

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse POP Quantification System
Published on: September 20, 2018
[A male with perianal skin abnormalities]
Sebastiaan A Pronk1,2, Mariska M P Muijres3, Luuk T J Levels3
1GGD Limburg-Noord, Centrum voor Seksuele Gezondheid, Venlo(tevens: Maastricht UMC+, afd. Intensive Care, Maastricht).
A man with perianal plaques was diagnosed with syphilis and herpes simplex virus (HSV) co-infection. Successful treatment involved benzathine benzylpenicillin, highlighting the importance of diagnosing co-infections in sexual health.
Area of Science:
- Infectious Diseases
- Dermatology
- Sexual Health
Background:
- Perianal pain and bleeding can indicate various conditions, including sexually transmitted infections.
- Co-infections are common in individuals with high-risk sexual behaviors.
Observation:
- A 23-year-old man presented with erosive perianal plaques, perianal pain, and blood loss.
- Diagnostic polymerase chain reaction (PCR) testing of perianal plaques revealed the presence of Treponema pallidum and herpes simplex virus (HSV) type 2.
Findings:
- The patient was diagnosed with primary or secondary syphilis co-infected with HSV type 2.
- Treatment with benzathine benzylpenicillin resulted in successful clinical recovery.
Implications:
- This case underscores the need for comprehensive STI screening in patients presenting with suggestive perianal lesions.
- Recognizing and treating co-infections like syphilis and HSV is crucial for effective patient management and preventing complications.
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