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[Antibiotic-induced acute kidney injury]
Laurens A T M Vissers1,2, Eelco C Brand1, Jasper F Kers3
1Universitair Medisch Centrum Utrecht, afd. Interne geneeskunde, Utrecht.
Nederlands Tijdschrift Voor Geneeskunde
|January 12, 2023
Summary
Antibiotic-induced acute kidney injury is a common, overlooked complication in hospitalized patients. This review details ciprofloxacin-related kidney injury, covering causes, diagnostics, and treatment.
Area of Science:
- Nephrology
- Pharmacology
- Internal Medicine
Context:
- Acute kidney injury (AKI) affects up to 20% of hospitalized patients.
- Antibiotics are an underrecognized cause of hospital-acquired AKI.
- Ciprofloxacin is a frequently prescribed antibiotic with nephrotoxic potential.
Purpose:
- To review the primary mechanisms of antibiotic-induced kidney injury.
- To illustrate antibiotic nephrotoxicity using two cases of ciprofloxacin-induced kidney injury: crystal nephropathy and tubulointerstitial nephritis.
- To discuss the pathophysiology, diagnosis, and management of antibiotic-associated AKI.
Summary:
- This article examines antibiotic-induced acute kidney injury (AKI), a frequent complication in hospitalized individuals.
- It focuses on two distinct forms of ciprofloxacin-induced nephrotoxicity: crystal nephropathy and tubulointerstitial nephritis.
- Key aspects covered include the underlying pathophysiology, common causative antibiotics, diagnostic approaches, and therapeutic strategies.
Impact:
- Enhances understanding of antibiotic-related kidney damage in clinical practice.
- Provides clinicians with insights into diagnosing and managing drug-induced AKI.
- Highlights the importance of considering medication side effects in AKI cases.
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