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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

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Updated: Aug 14, 2025

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

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[A bleeding tumor on the scalp].

Anouk K M Claessens^1,2, Jos G U Ridderbeks¹

¹Huisartsenpraktijk Ulestraten, Ulestraten.

Nederlands Tijdschrift Voor Geneeskunde

|January 12, 2023

Summary

This summary is machine-generated.

An elderly man presented with a large, bleeding head tumor. Diagnosis confirmed poorly differentiated squamous cell carcinoma, with bone erosion but no lymph node involvement.

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Area of Science:

Oncology
Dermatology
Pathology

Background:

Squamous cell carcinoma (SCC) is a common skin cancer.
Delayed medical visits, particularly during the COVID-19 pandemic, can impact cancer diagnosis and staging.

Observation:

An 83-year-old male patient presented with a significant ulcerated and bleeding head tumor measuring 5.5x5x3 cm.
The patient had delayed seeking medical attention due to concerns related to the COVID-19 pandemic.

Findings:

Histopathological analysis confirmed the tumor as poorly differentiated squamous cell carcinoma.
Imaging revealed erosion of the external bone layer (tabula externa) of the skull.
No evidence of metastatic spread to regional lymph nodes was detected.

Implications:

This case highlights the importance of timely diagnosis and treatment for aggressive skin cancers, even amidst public health crises.
The findings underscore the potential for locally advanced squamous cell carcinoma to cause significant local destruction.
Further investigation into patient factors influencing delayed presentation for dermatological conditions is warranted.