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Updated: Aug 14, 2025

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
Published on: February 7, 2017
Ice recrystallization inhibition mechanism of zwitterionic poly(carboxybetaine methacrylate)
Yanfang Chen1, Xiaojie Sui2, Tiantong Zhang1
1School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China. yhan@tju.edu.cn.
Abstract:
Understanding the ice recrystallization inhibition (IRI) mechanism is of fundamental importance for the rational design of novel antifreeze protein mimetics and reducing IR-related damage. In this communication, using quantitive experimental methods and molecular dynamics simulations we demonstrate that zwitterionic poly(carboxybetaine methacrylate) (PCBMA) can serve as a novel IRI-active substance. This work unravels the atomic-level details of the IRI mechanism of zwitterionic antifreeze protein mimetics and provides insight into the development of next-generation antifreeze protein mimetics.
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