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Off the RADAR; questions regarding the trial protocol of a randomised controlled trial of antipsychotic reduction and
Sameer Jauhar1, Paolo Fusar-Poli2, David Foreman3
1Department of Psychological Medicine, IoPPN, King's College, London, UK.
Abstract:
The randomised controlled trial of antipsychotic reduction and discontinuation addresses essential questions with regard to continued use of antipsychotics in schizophrenia, pertaining to social functioning and continued antipsychotic use. However, significant methodological issues stated in the trial protocol have the potential to confound interpretation of any findings. These include use of a non-blinded outcome measure, treatment as usual comparator and possible sample size issues.
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