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The relationship between hyperhomocysteinemia and total coronary artery occlusion: a cross-sectional study from

Kaiyong Xiao1, Yuxiong Chen2, Lian Xiao1

  • 1Department of Cardiology, Guangyuan Central Hospital, Lizhou District, Guangyuan, Sichuan.

Coronary Artery Disease
|January 12, 2023
PubMed

Insights

High homocysteine levels (hyperhomocysteinemia) significantly increase the risk of total coronary artery occlusion (TCAO). This association is notable in men, older individuals, smokers, and those without diabetes.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Metabolic Syndrome

Background:

  • Hyperhomocysteinemia is an emerging risk factor for coronary artery disease.
  • Limited research exists on the link between hyperhomocysteinemia and total coronary artery occlusion (TCAO).
  • Understanding TCAO risk factors, including hyperhomocysteinemia, is crucial for cardiovascular health.

Purpose of the Study:

  • To investigate the association between hyperhomocysteinemia and TCAO in a Southwest Chinese population.
  • To explore interactions between hyperhomocysteinemia and traditional cardiovascular risk factors for TCAO.

Main Methods:

  • Cross-sectional study of 890 adult patients.
  • Defined TCAO as complete occlusion of >1 coronary segment.
  • Defined hyperhomocysteinemia as serum homocysteine ≥15 μmol/L.
  • Utilized multivariable logistic regression and subgroup analyses.

Main Results:

  • Hyperhomocysteinemia was significantly associated with an increased risk of TCAO (OR 1.74).
  • Elevated homocysteine as a continuous variable also correlated with higher TCAO risk.
  • The association was significant in men, elderly, overweight, smokers, and non-diabetic individuals.

Conclusions:

  • Hyperhomocysteinemia is a significant risk factor for TCAO in Southwest China.
  • Specific subgroups, including men, the elderly, overweight individuals, smokers, and non-diabetics, face a heightened risk.
  • Further research may elucidate mechanisms and inform targeted prevention strategies.
Abstract

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