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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Aug 14, 2025

Author Spotlight: Advancements in Refractive Surgical Correction for Presbyopia and Exploring Postoperative Visual Acuity
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Electromechanical Cornea Reshaping for Refractive Vision Therapy.

Anna M Stokolosa1, Jack Thomas-Colwell1, Katelyn K Dilley2

  • 1Department of Chemistry, Occidental College, Los Angeles, California 90041, United States.

ACS Biomaterials Science & Engineering
|January 12, 2023
PubMed
Summary
This summary is machine-generated.

Electromechanical reshaping (EMR) offers a novel, nonsurgical method for vision correction by altering corneal curvature. This electrochemical technique precisely reshapes the cornea, maintaining transparency and cellular health for potential refractive error treatment.

Keywords:
corneaelectrochemistryoptical coherence tomography (OCT)stress-relaxationvision refraction

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Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Biomedical Engineering

Background:

  • The corneal stroma's collagen lamellae dictate eye shape and refractive power.
  • Current vision correction methods are often surgical or invasive.

Purpose of the Study:

  • To investigate electromechanical reshaping (EMR) as a nonsurgical approach for vision correction.
  • To assess the feasibility of altering corneal curvature using EMR.

Main Methods:

  • EMR utilizes electrochemical pulses to alter corneal tissue properties.
  • Protonation of the extracellular matrix enables transient mechanical remodeling.
  • Ex vivo rabbit eyes were used to test the EMR procedure.

Main Results:

  • EMR successfully induced controlled changes in corneal curvature across a range of refractive powers.
  • Optical transparency of the cornea was preserved post-EMR.
  • Optical coherence tomography and microscopy confirmed precise contouring without damaging collagen structure or cell viability.

Conclusions:

  • EMR is a viable technique for precise corneal contouring.
  • Electrochemical vision therapy presents a promising, potentially low-cost method for refractive error correction.