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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Aug 14, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

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Intraventricular immunovirotherapy; a translational step forward.

Joshua D Bernstock1,2, Sarah Blitz1, Kyung-Don Kang3

  • 1Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Oncotarget
|January 12, 2023
PubMed
Summary

Intraventricular administration of oncolytic herpes simplex virus (oHSV) offers a new treatment option for brain tumors, including those in difficult-to-reach areas. This method shows promise for treating metastatic disease and enables repeated dosing of immunovirotherapy.

Keywords:
G207herpes simplex virus (HSV)intraventricular therapyleptomeningeal diseaseoncolytic virotherapy

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Area of Science:

  • Oncolytic virotherapy
  • Neuro-oncology
  • Gene therapy

Background:

  • Intratumoral engineered type-1 herpes simplex virus (HSV) shows safety and efficacy for high-grade glioma.
  • Current delivery methods limit treatment for surgically inaccessible tumors, spinal cord metastases, and leptomeningeal disease.

Purpose of the Study:

  • To investigate the clinical translation of intraventricular administration of oncolytic herpes simplex virus (oHSV).
  • To identify and mitigate toxicity associated with intraventricular oHSV delivery.
  • To establish a feasible method for repetitive dosing of oHSV immunovirotherapy.

Main Methods:

  • Preclinical studies in murine models of disseminated medulloblastoma.
  • Evaluation of intraventricular administration route for oHSV.
  • Identification and mitigation strategies for oHSV-related toxicity.

Main Results:

  • Intraventricular oHSV administration demonstrated therapeutic benefit in preclinical models.
  • Strategies were identified to mitigate toxicity associated with this delivery route.
  • The approach shows potential for treating disseminated and intractable brain tumors.

Conclusions:

  • Intraventricular oHSV administration is a promising strategy for treating brain tumors, including those in surgically inaccessible regions.
  • This method expands treatment options for metastatic and leptomeningeal disease.
  • The study supports repetitive dosing of oHSV, such as G207, for enhanced immunovirotherapy.