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Related Experiment Video

Updated: Aug 14, 2025

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
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NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022.

Craig Horbinski1, Louis Burt Nabors2, Jana Portnow3

  • 1Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

Journal of the National Comprehensive Cancer Network : JNCCN
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The National Comprehensive Cancer Network (NCCN) updated guidelines for adult Central Nervous System (CNS) cancers, including gliomas and brain metastases. These recommendations emphasize molecular profiling for improved glioma management.

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Area of Science:

  • Neuro-oncology
  • Clinical Oncology
  • Cancer Genetics

Background:

  • The National Comprehensive Cancer Network (NCCN) provides guidelines for managing adult Central Nervous System (CNS) cancers.
  • These guidelines cover a range of primary and metastatic brain and spinal cord tumors.

Purpose of the Study:

  • To summarize recent updates to the NCCN Guidelines for CNS Cancers.
  • To highlight key recommendations for the management of adult CNS tumors, particularly focusing on molecular profiling in gliomas.

Main Methods:

  • The NCCN CNS Cancers Panel annually reviews new data, publications, and reviewer comments.
  • Recommendations are updated based on the latest scientific evidence and clinical insights.

Main Results:

  • The updated guidelines provide a framework for managing various adult CNS cancers, including gliomas, ependymomas, medulloblastomas, and metastases.
  • Recent recommendations emphasize the importance of molecular profiling for gliomas.

Conclusions:

  • The NCCN Guidelines offer essential principles for surgical, radiotherapeutic, and systemic therapy for CNS tumors.
  • Continuous updates ensure clinicians have access to current best practices for complex CNS cancer management.