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NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022
Craig Horbinski1, Louis Burt Nabors2, Jana Portnow3
1Robert H. Lurie Comprehensive Cancer Center of Northwestern University.
Abstract:
The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of the following adult CNS cancers: glioma (WHO grade 1, WHO grade 2-3 oligodendroglioma [1p19q codeleted, IDH-mutant], WHO grade 2-4 IDH-mutant astrocytoma, WHO grade 4 glioblastoma), intracranial and spinal ependymomas, medulloblastoma, limited and extensive brain metastases, leptomeningeal metastases, non-AIDS-related primary CNS lymphomas, metastatic spine tumors, meningiomas, and primary spinal cord tumors. The information contained in the algorithms and principles of management sections in the NCCN Guidelines for CNS Cancers are designed to help clinicians navigate through the complex management of patients with CNS tumors. Several important principles guide surgical management and treatment with radiotherapy and systemic therapy for adults with brain tumors. The NCCN CNS Cancers Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. These NCCN Guidelines Insights summarize the panel's most recent recommendations regarding molecular profiling of gliomas.
Insights
The National Comprehensive Cancer Network (NCCN) updated guidelines for adult Central Nervous System (CNS) cancers, including gliomas and brain metastases. These recommendations emphasize molecular profiling for improved glioma management.
Area of Science:
- Neuro-oncology
- Clinical Oncology
- Cancer Genetics
Background:
- The National Comprehensive Cancer Network (NCCN) provides guidelines for managing adult Central Nervous System (CNS) cancers.
- These guidelines cover a range of primary and metastatic brain and spinal cord tumors.
Purpose of the Study:
- To summarize recent updates to the NCCN Guidelines for CNS Cancers.
- To highlight key recommendations for the management of adult CNS tumors, particularly focusing on molecular profiling in gliomas.
Main Methods:
- The NCCN CNS Cancers Panel annually reviews new data, publications, and reviewer comments.
- Recommendations are updated based on the latest scientific evidence and clinical insights.
Main Results:
- The updated guidelines provide a framework for managing various adult CNS cancers, including gliomas, ependymomas, medulloblastomas, and metastases.
- Recent recommendations emphasize the importance of molecular profiling for gliomas.
Conclusions:
- The NCCN Guidelines offer essential principles for surgical, radiotherapeutic, and systemic therapy for CNS tumors.
- Continuous updates ensure clinicians have access to current best practices for complex CNS cancer management.
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