NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022.

Area of Science:

• Neuro-oncology
• Clinical Oncology
• Cancer Genetics

Background:

• The National Comprehensive Cancer Network (NCCN) provides guidelines for managing adult Central Nervous System (CNS) cancers.
• These guidelines cover a range of primary and metastatic brain and spinal cord tumors.

Purpose of the Study:

• To summarize recent updates to the NCCN Guidelines for CNS Cancers.
• To highlight key recommendations for the management of adult CNS tumors, particularly focusing on molecular profiling in gliomas.

Main Methods:

• The NCCN CNS Cancers Panel annually reviews new data, publications, and reviewer comments.
• Recommendations are updated based on the latest scientific evidence and clinical insights.

Main Results:

• The updated guidelines provide a framework for managing various adult CNS cancers, including gliomas, ependymomas, medulloblastomas, and metastases.
• Recent recommendations emphasize the importance of molecular profiling for gliomas.

Conclusions:

• The NCCN Guidelines offer essential principles for surgical, radiotherapeutic, and systemic therapy for CNS tumors.
• Continuous updates ensure clinicians have access to current best practices for complex CNS cancer management.