Antibodies face the challenge against human respiratory syncytial virus

In the December 22 issue of Cell, Bartsch et al. describe functional profiling of the antibody response to respiratory syncytial virus in human adults vaccinated with an experimental adenovirus-based prefusion-stabilized HRSV-F vaccine and subsequently intranasally challenged with HRSV. The authors identified various antibody effector functions as humoral correlates of protection.