Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods.

Nature communications·2026

Same author

Affinity- and epitope-dependent pathogenicity of GM-CSF autoantibodies in patients with autoimmune pulmonary alveolar proteinosis.

Nature communications·2026

Same author

Endothelial cell expression of STING<sup>V154M</sup>: Gain-of-function mutation delays the resolution of UVB-induced skin injury.

The Journal of investigative dermatology·2026

Same author

Tumor Homing Nanoparticle Immunotherapy for Acute Clearance and Mitigation of T-cell Exhaustion in Humanized High-Risk Neuroblastoma.

Molecular cancer therapeutics·2026

Same author

Building a diagnostic scoring system for high-grade neuroendocrine neoplasms of the pancreas.

American journal of clinical pathology·2026

Same author

Crystallized colony-stimulating factor-1 receptor inhibitor protects immunoisolated allo but not xeno transplants in primates.

Science translational medicine·2026

Search research articles

Related Experiment Video

Updated: Aug 14, 2025

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

Humanized mouse models for immuno-oncology research.

Jane Chuprin^1,2, Hannah Buettner^1,3, Mina O Seedhom¹

¹Program in Molecular Medicine, The University of Massachusetts Chan Medical School, Worcester, MA, USA.

Nature Reviews. Clinical Oncology

|January 12, 2023

Summary

This summary is machine-generated.

Humanized mice models are crucial for advancing cancer immunotherapy research by enabling the study of human immune system and tumor interactions. These models offer valuable insights into treatment efficacy and biomarker development for clinical translation.

More Related Videos

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery

Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery

Published on: September 27, 2021

Related Experiment Videos

Last Updated: Aug 14, 2025

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery

Production of Humanized Mouse via Thymic Renal Capsule Grafting, CD34+ Cells Injection, and Cytokine Delivery

Published on: September 27, 2021

Area of Science:

Oncology
Immunology
Preclinical Research

Background:

Immunotherapy shows promise for cancer treatment but has variable responses and unclear mechanisms.
Limited preclinical models exist to study human immune-tumor interactions and human-specific immunotherapies in vivo.
Humanized mice, co-engrafted with human tumors and immune components, offer advantages for immuno-oncology research.

Purpose of the Study:

To review the benefits and challenges of current humanized mouse models for immuno-oncology.
To discuss specific interactions between engrafted human tumors and immune components in these models.
To highlight advances in generating humanized mouse models for clinical translation.

Main Methods:

Review of existing literature on humanized mouse models.
Analysis of human tumor and immune cell engraftment in immunodeficient mice.
Evaluation of human innate immune cell development and survival in vivo.

Main Results:

Humanized mice facilitate the study of human-specific immune responses against tumors.
These models allow for investigation of tumor-immune cell interactions and immune cell development.
Approaches using matched patient tumors and immune cells are being developed.

Conclusions:

Humanized mouse models are essential tools for advancing cancer immunotherapy research.
Understanding their benefits and challenges is key to their effective application.
These models hold significant potential for clinical translation in immuno-oncology.