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Triglyceride glucose index is associated with obstructive coronary artery disease in hypertensive patients

Weili Pan1, Yongkui Ren1, Fan Yang2

  • 1Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.

Cardiovascular Diabetology
|January 12, 2023
PubMed

Insights

The triglyceride glucose (TyG) index is linked to a higher risk of obstructive coronary artery disease (OCAD) in patients with hypertension. Higher TyG index values indicate an increased likelihood of developing OCAD.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Hypertension is a primary risk factor for coronary artery disease (CAD).
  • The triglyceride glucose (TyG) index serves as a marker for insulin resistance (IR).
  • Limited research exists on the association between the TyG index and the incidence of obstructive CAD (OCAD) in hypertensive individuals.

Purpose of the Study:

  • To investigate the relationship between the TyG index and the incidence of OCAD in hypertensive patients.
  • To determine if the TyG index can predict the development of OCAD in this population.

Main Methods:

  • A retrospective study involving 1841 hypertensive patients without prior CAD history.
  • Coronary computed tomography angiography (CCTA) was used to diagnose OCAD (stenosis ≥50%).
  • The TyG index was calculated using fasting triglycerides and glucose levels.

Main Results:

  • 310 patients (16.8%) developed OCAD.
  • A J-shaped relationship was observed between TyG index and OCAD incidence.
  • Elevated TyG index tertiles (T2 and T3) were significantly associated with increased OCAD risk compared to the lowest tertile (T1).
  • A 1-SD increase in TyG index raised OCAD risk by 49%.

Conclusions:

  • The TyG index is significantly associated with the incidence of obstructive CAD in hypertensive patients.
  • The TyG index may serve as a valuable predictive marker for OCAD in hypertensive individuals.
Abstract

Keywords:
Hypertensive patientsObstructive CADTyG index

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