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Effects of Arum dioscoridis Extract on Hepatic Toxicity Caused by Thioacetamide in Rats

Murat Fatih Sökmen1, Murat İspiroğlu2, Kadir Gişi2

  • 1Department of Internal Medicine, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey.

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
|January 13, 2023
PubMed
Abstract

Insights

Arum dioscoridis plant extract demonstrates both prophylactic and therapeutic effects against thioacetamide-induced liver toxicity in rats. This natural compound shows promise for treating acute liver injury and hepatotoxicity.

Area of Science:

  • Pharmacology
  • Toxicology
  • Natural Products Chemistry

Background:

  • Investigates the impact of thioacetamide (TAA) in inducing experimental liver toxicity.
  • Highlights the need for effective and accessible treatments for acute liver injury.

Purpose of the Study:

  • To evaluate the prophylactic and therapeutic potential of Arum dioscoridis extract against TAA-induced hepatotoxicity.
  • To assess the extract's effects on liver enzymes and oxidative stress markers.

Main Methods:

  • Utilized 35 male Wistar-Albino rats, divided into control, hepatotoxicity, prophylaxis, and two treatment groups.
  • Induced hepatotoxicity using a single intraperitoneal dose of 350 mg/kg thioacetamide.
  • Analyzed serum liver enzymes, and liver tissue levels of Malondialdehyde (MDA), Glutathione Peroxidase (GPx), Catalase (CAT), and Superoxide Dismutase (SOD), alongside histopathological evaluation.

Main Results:

  • Arum dioscoridis administration led to significant improvements in measured biochemical parameters.
  • Treatment with the plant extract resulted in increased antioxidant enzyme levels in liver tissues.
  • Histopathological analysis supported the protective and restorative effects of Arum dioscoridis.

Conclusions:

  • Arum dioscoridis extract exhibits significant prophylactic and therapeutic efficacy in mitigating experimental liver toxicity.
  • The findings suggest Arum dioscoridis as a potential effective and economical therapeutic agent for acute liver injury and hepatotoxicity.
  • Further research into the active compounds and mechanisms of Arum dioscoridis is warranted.

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