Related Experiment Video

Updated: Jul 30, 2026

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
11:56

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

11.2K

Effects of Mouthwash on Oral Cytomegalovirus, Epstein-Barr Virus, Herpes Simplex Virus Type-1

Hessam Nowzari1, Petra Wilder-Smith2

  • 1Private Practice, Beverly Hills, California, USA.

Advances in Clinical and Medical Research (Chandigarh, India)
|January 13, 2023
PubMed
Abstract

Insights

Lumineux Mouthwash, containing Dead Sea salt, significantly reduced oral viral load in a 60-day study. This mouthwash offers a promising approach to managing viral pathogens like HCMV, EBV, and HSV-1.

Area of Science:

  • Oral microbiology
  • Virology
  • Clinical research

Background:

  • Human Cytomegalovirus (HCMV), Epstein-Barr virus (EBV), and herpes simplex virus type-1 (HSV-1) are common viral pathogens.
  • These viruses can cause various oral health issues.

Purpose of the Study:

  • To compare the efficacy of Lumineux Mouthwash versus de-ionized water in reducing oral viral load.
  • To evaluate the effect of a Dead Sea salt-based mouthwash on salivary viral load over 60 days.

Main Methods:

  • A double-blinded, randomized study involving 30 participants.
  • Participants used either Lumineux Mouthwash or de-ionized water twice daily for 60 days.
  • Saliva samples were collected at baseline and day 60 for mRNA analysis to measure changes in Log Salivary Viral Load.

Main Results:

  • The Lumineux Mouthwash group showed a significantly greater reduction in viral load compared to the control group (p < 0.001).
  • The observed differences in viral load reduction were consistent regardless of baseline viral load levels.

Conclusions:

  • Lumineux Mouthwash, formulated with Dead Sea salt, effectively reduces oral viral load.
  • The study supports the use of this mouthwash as a potential intervention for managing oral viral infections.
Keywords:
CMVCytomegalovirusEpstein-Barr virusHCMVPeriodontitis

More Related Videos

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi12:33

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Published on: July 6, 2016

9.7K
Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals08:31

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals

Published on: September 20, 2021

3.4K

Related Concept Videos

Surface Membrane Barriers01:18

Surface Membrane Barriers

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Antiviral Nucleoside Inhibitors01:22

Antiviral Nucleoside Inhibitors

Antiviral Nucleoside InhibitorsAntiviral nucleoside inhibitors are structural analogs of natural nucleosides that interfere with viral DNA or RNA synthesis. These compounds selectively target viral polymerases due to their resemblance to host nucleosides, thereby disrupting viral genome replication.Mechanism of Acyclovir ActionAcyclovir is a guanosine analog with a three-carbon acyclic side chain. It selectively targets herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2),...