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Perspectives in prospective comparative economic evaluations: a systematic review.

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Most health economic studies align with country guidelines on chosen perspectives. However, the relevance of these perspectives should be adapted to the specific research question and pathology.

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Area of Science:

  • Health Economics
  • Pharmacoeconomics
  • Health Technology Assessment

Background:

  • Medico-economic assessment guidelines vary by country and health system, recommending specific perspectives for study analysis.
  • A systematic literature review was conducted to evaluate the alignment between national guidelines and the perspectives adopted in published health economic studies.

Approach:

  • Searches were performed on the Medline database for studies published between January 2000 and August 2020.
  • Included studies were from countries with publicly available guidelines on recommended perspectives for medico-economic assessments.

Key Points:

  • Out of 398 studies, 54.9% used a public payer perspective, 36.5% a societal perspective, 6.5% a hospital perspective, and 2.1% a patient perspective.
  • 67.1% of studies followed guideline recommendations, particularly those from Canada, the UK, and the Netherlands.
  • Two-thirds of the chosen perspectives aligned with recommendations.

Conclusions:

  • While study quality is not questioned, the choice of perspective is crucial.
  • Perspectives must be adapted to the specific research question, pathology, and study feasibility for optimal relevance.