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Updated: Aug 14, 2025
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
Molecular insights and therapeutic implications of nanoengineered dietary polyphenols for targeting lung cancer: part
Sabya Sachi Das1,2, Srushti Tambe3, Priya Ranjan Prasad Verma1
1Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.
Abstract:
Flavonoids represent a major group of polyphenolic compounds. Their capacity to inhibit tumor proliferation, cell cycle, angiogenesis, migration and invasion is substantially responsible for their chemotherapeutic activity against lung cancer. However, their clinical application is limited due to poor aqueous solubility, low permeability and quick blood clearance, which leads to their low bioavailability. Nanoengineered systems such as liposomes, nanoparticles, micelles, dendrimers and nanotubes can considerably enhance the targeted action of the flavonoids with improved efficacy and pharmacokinetic properties, and flavonoids can be successfully translated from bench to bedside through various nanoengineering approaches. This review addresses the therapeutic potential of various flavonoids and highlights the cutting-edge progress in the nanoengineered systems that incorporate flavonoids for treating lung cancer.
Insights
Flavonoids show promise for lung cancer treatment but have low bioavailability. Nanoengineered systems improve their delivery and effectiveness, advancing their clinical application.
Area of Science:
- Biochemistry
- Pharmacology
- Oncology
Background:
- Flavonoids are polyphenolic compounds with demonstrated chemotherapeutic activity against lung cancer.
- Their clinical use is hindered by poor solubility, low permeability, and rapid clearance, resulting in low bioavailability.
- Targeted delivery is crucial for overcoming these limitations in lung cancer therapy.
Purpose of the Study:
- To review the therapeutic potential of various flavonoids in lung cancer treatment.
- To highlight advancements in nanoengineered systems for enhancing flavonoid efficacy and delivery.
- To explore the translation of flavonoids into clinical applications for lung cancer.
Main Methods:
- Literature review of flavonoid properties and nanoengineering strategies.
- Analysis of nanoengineered systems (liposomes, nanoparticles, micelles, dendrimers, nanotubes) for flavonoid delivery.
- Evaluation of enhanced pharmacokinetic properties and targeted action of nano-flavonoids.
Main Results:
- Flavonoids exhibit significant potential in inhibiting tumor proliferation, cell cycle, angiogenesis, migration, and invasion.
- Nanoengineered systems substantially improve flavonoid bioavailability, efficacy, and targeted action.
- Various nanoengineering approaches facilitate the clinical translation of flavonoids for lung cancer.
Conclusions:
- Nanoengineered flavonoids offer a promising strategy to overcome bioavailability challenges in lung cancer therapy.
- Advancements in nanotechnology enhance the therapeutic efficacy and pharmacokinetic profiles of flavonoids.
- The integration of nanoengineering holds significant potential for the successful clinical application of flavonoids against lung cancer.
