Association between Serum α-Klotho Levels and Behçet Disease.
Mohammad Reza Jafari Nakhjavani1, Amir Ghorbanihaghjo2, Aida Malek Mahdavi1,3,4
1Connective Tissue Diseases Research Center.
Laboratory Medicine
|January 13, 2023
Summary
Serum levels of α-klotho were significantly lower in patients with Behçet disease (BD) compared to healthy individuals. Lower α-klotho may indicate a role in endothelial dysfunction and serve as a biomarker for uveitis in BD.
Area of Science:
- Endocrinology and Metabolism
- Vascular Biology
- Rheumatology
Background:
- Endothelial dysfunction (ED) contributes to vascular inflammation in Behçet disease (BD).
- Reduced levels of α-klotho are associated with ED.
- α-klotho plays a role in regulating endothelial function.
Purpose of the Study:
- To compare serum α-klotho levels in patients with Behçet disease (BD) against healthy controls.
- To investigate the potential role of α-klotho in the pathogenesis of ED within BD.
Main Methods:
- A cross-sectional study involving 55 BD patients and 30 healthy controls.
- Serum α-klotho levels were measured in all participants.
- Clinical symptoms and demographic data were recorded.
Main Results:
- Median serum α-klotho levels were significantly lower in BD patients (0.30 ng/mL) than in controls (1.00 ng/mL) (P=.005).
- No significant correlation was found between serum α-klotho and age.
- Patients with uveitis exhibited significantly lower serum α-klotho levels.
Conclusions:
- α-klotho may be implicated in the development of endothelial dysfunction in Behçet disease.
- Serum α-klotho levels could serve as a potential biomarker for identifying uveitis in BD patients.
Keywords:
Behçet diseaseendothelial dysfunctionklotho proteinssuperoxide dismutase 2vasculitisα-klothoMore Related Videos
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