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Differential Proteins Expression Distinguished Between Patients With Infectious and Noninfectious Uveitis
Carmen L Pessuti1, Quintus G Medley2, Ning Li2
1Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil.
Ocular Immunology and Inflammation
|January 13, 2023
Summary
Researchers identified unique protein signatures in aqueous humor and plasma to differentiate between infectious uveitis and noninfectious uveitis, aiding in biomarker discovery.
Area of Science:
- Ophthalmology
- Proteomics
- Immunology
Background:
- Uveitis, an inflammatory eye condition, can be infectious or noninfectious, posing diagnostic challenges.
- Accurate differentiation is crucial for appropriate treatment and patient outcomes.
Purpose of the Study:
- To investigate and compare the proteomic profiles of aqueous humor and plasma in patients with infectious uveitis (IU) and noninfectious uveitis (NIU).
- To identify potential protein biomarkers that can distinguish between IU and NIU.
Main Methods:
- Aqueous humor (AH) and plasma samples were collected from 28 IU patients, 29 NIU patients, and 35 healthy controls.
- SomaScan technology was employed to analyze the protein profiles of the collected samples.
Main Results:
- Significant alterations in protein expression were observed in both AH and plasma for IU and NIU groups compared to controls.
- Pathway enrichment analysis indicated involvement of inflammatory and regulatory processes in both uveitis types.
- Specific protein signatures were identified in AH and plasma that could differentiate between IU and NIU.
Conclusions:
- SomaScan technology effectively identified novel protein biomarkers in AH and plasma for IU and NIU.
- The distinct protein profiles in AH and plasma suggest a potential diagnostic signature for differentiating infectious from noninfectious uveitis.
