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Updated: Aug 15, 2026

Prion Safety Laboratory Swipe Test
Published on: February 14, 2025
Proof of safety vs proof of hazard
1Department of Biostatistics, University of Washington, Seattle 98195.
Abstract:
This paper refines and extends the work of Bross (1985, Biometrics 41, 785-793). One method to determine whether an environment is safe or hazardous is to frame the problem in the context of hypothesis testing. Any "proof" of safety or hazard will depend on the size of both the Type I and Type II errors associated with the test. Many past environmental monitoring programs, however, have ignored the power of the design, regardless of whether the objective was proof of safety or hazard.
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Types of Hypothesis Testing
When the null and alternative hypotheses are stated, it is observed that the null hypothesis is a neutral statement against which the alternative hypothesis is tested. The alternative hypothesis is a claim that instead has a certain direction. If the null hypothesis claims that p = 0.5, the alternative hypothesis would be an opposing statement to this and can be put either p > 0.5, p < 0.5, or p ≠ 0.5.
Criteria for Causality: Bradford Hill Criteria - II
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