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Fluctuations in Pediatric Acute Otitis Media Burden During the First Two COVID-19 Years in Israel
Elchanan Zloczower1,2, Jacob Pitaro1,3, Itai Hazan4,5
1Clalit Health Services, Tel Aviv, Israel.
Insights
Pediatric acute otitis media (AOM) burden significantly decreased during the COVID-19 pandemic due to airborne disease control measures. However, AOM rates nearly returned to pre-pandemic levels by the second year of the pandemic.
Area of Science:
- Epidemiology
- Infectious Diseases
- Public Health
Background:
- The COVID-19 pandemic introduced measures to curb airborne disease transmission.
- Understanding the impact of these measures on pediatric acute otitis media (AOM) burden is crucial.
- Urinary tract infection (UTI) was used as a comparative infection to assess AOM fluctuations.
Purpose of the Study:
- To analyze changes in pediatric acute otitis media (AOM) incidence.
- To compare AOM burden fluctuations before and during the initial two years of the COVID-19 pandemic.
- To evaluate the impact of public health interventions on AOM rates.
Main Methods:
- A cross-sectional study design was employed, comparing three pre-COVID years with the first two COVID years (2017-2022).
- Data were extracted from the Clalit Health Services database, covering children aged 0-15 years.
- Incidence rate ratios (IRRs) were calculated to compare AOM and UTI episode rates between the pre-pandemic and pandemic periods.
Main Results:
- A significant reduction in AOM episode rates (IRR 0.46) was observed during the COVID years, more than double the decrease seen in UTI rates (IRR 0.76).
- The most substantial decrease in AOM occurred among children aged 1-4 years during the first COVID year.
- Recent COVID-19 infection was strongly associated with lower AOM morbidity (IRR 0.05).
Conclusions:
- The burden of pediatric acute otitis media (AOM) substantially decreased during the first year of the COVID-19 pandemic.
- AOM rates showed a partial recovery, nearing pre-pandemic levels by the second year of the pandemic.
- Public health measures implemented during the pandemic significantly impacted pediatric AOM incidence.
Background:
To study pediatric acute otitis media (AOM) burden fluctuations before and during the first two COVID years, which were characterized by measures to reduce the spread of airborne diseases. We used urinary tract infection (UTI) as a comparison infection.
Methods:
This was a cross-sectional study encompassing three pre-COVID years (March 1, 2017-February 29, 2020) and the first two COVID years (March 1, 2020-February 28, 2021, and March 1, 2021-February 28, 2022). Records were retrieved from the Clalit Health Services database, Israel's largest healthcare maintenance organization. Children 0-15 years with AOM and UTI episodes were categorized according to age (1>, 1-4, 5-15 years). We collected demographics, seasonality, AOM complications, antibiotic prescriptions, and recent COVID-19 infections. The average AOM/UTI rates of the three pre-COVID years vs. two COVID years were used to calculate the incidence rate ratios (IRRs).
Results:
We identified 1,102,826 AOM and 121,263 UTI episodes. The median age at AOM diagnosis was 2.0 years (IQR, 1.1-4.1). Male predominance, age at presentation, and the dominant age group of 1-4 years did not change during the COVID years. While UTI episode rates decreased during the COVID years (IRR 0.76, 95% CI, 0.68-0.84, P < 0.001), the reduction in AOM episode rates was >2-fold (IRR 0.46, 95% CI, 0.34-0.63, P < 0.001). The largest decrease was observed among children 1-4 years old during the first COVID year (β=-1,938 AOM episodes/100,00 children, 95% CI, -2,038 to -1,912, P < 0.001). Recent COVID-19 infection was associated with low AOM morbidity (IRR 0.05, 95% CI 0.05-0.05, P < 0.001).
Conclusions:
AOM burden substantially decreased during the first COVID year but almost reached pre-pandemic levels during the second year.
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