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Striatin family proteins: The neglected scaffolds

Goutam Kumar Tanti1, Prachi Pandey2, Smriti Shreya3

  • 1Department of Neurology, School of Medicine, Technical University of Munich, Germany.

Biochimica Et Biophysica Acta. Molecular Cell Research
|January 13, 2023
PubMed

Insights

The Striatin protein family, including Zinedin and SG2NA, acts as a signaling scaffold involved in cancer cell proliferation and cell cycle regulation. This review elaborates on their structure, function, and role in STRIPAK complexes.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The Striatin protein family comprises Striatin, SG2NA, and Zinedin, functioning as signaling scaffolds with multiple protein-protein interaction domains.
  • SG2NA and Zinedin are implicated in cancer cell proliferation, with SG2NA exhibiting complex post-transcriptional regulation and alternative splicing.
  • Striatin also undergoes alternative splicing, generating diverse isoforms.

Purpose of the Study:

  • To comprehensively review the structural and functional aspects of the Striatin protein family.
  • To elucidate the involvement of Striatin proteins in STRIPAK complexes and their functional significance.

Main Methods:

  • Literature review of existing research on the Striatin protein family.
  • Analysis of structural and functional data from various studies.
  • Examination of the role of Striatin proteins in signaling pathways and complexes.

Main Results:

  • Striatin family members possess multiple protein-protein interaction domains, enabling their role as signaling scaffolds.
  • SG2NA and Striatin exhibit alternative splicing, leading to multiple isoforms with tissue-specific regulation.
  • Striatin proteins are integral components of the STRIPAK complex, influencing signaling networks.

Conclusions:

  • The Striatin protein family plays crucial roles in estrogen signaling, neuroprotection, cancer, and cell cycle regulation.
  • Understanding the structural and functional diversity of Striatin isoforms is key to deciphering their complex roles in cellular processes.
  • The involvement in STRIPAK complexes highlights the Striatin family's importance in intricate cellular signaling networks.
Keywords:
CancerNeurodegenerationSTRIPAKStriatinWD40 domain

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