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Updated: Aug 14, 2025

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
04:01

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Published on: June 14, 2024

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Gut microbiota involved in myocardial dysfunction induced by sepsis

Kaihao Xiao1, Yan Sun2, Jiayu Song1

  • 1Department of Neonatology, Zhuhai Women and Children' s Hospital, Zhuhai, 519060, China.

Microbial Pathogenesis
|January 13, 2023
PubMed

Insights

Sepsis disrupts gut microbiota, leading to myocardial dysfunction and death. Understanding how gut bacteria influence heart injury in sepsis can improve patient outcomes.

Area of Science:

  • Microbiology
  • Cardiology
  • Pathophysiology

Background:

  • Sepsis-induced myocardial dysfunction is a major cause of mortality.
  • Sepsis significantly alters gut microbiota composition.
  • Gut microbiota dysbiosis contributes to sepsis development and progression.

Purpose of the Study:

  • To review the mechanisms by which gut microbiota influences myocardial injury during sepsis.
  • To explore the role of gut microbiota in sepsis pathophysiology.

Main Methods:

  • Literature review of studies investigating the gut-heart axis in sepsis.
  • Analysis of proposed molecular and cellular pathways.

Main Results:

  • Gut microbiota impacts myocardial function through metabolites like short-chain fatty acids and trimethylamine-N-oxide.
  • Cytokines and mitochondrial dysfunction are key mediators linking gut dysbiosis to cardiac injury.
  • Alterations in gut microbiota composition are directly implicated in sepsis-related heart problems.

Conclusions:

  • Gut microbiota plays a critical role in sepsis-induced myocardial injury.
  • Targeting gut microbiota may offer novel therapeutic strategies for sepsis.
  • Further research into the gut-heart axis is crucial for improving sepsis patient prognosis.
Keywords:
Gut microbiotaMyocardial dysfunctionPathogenesisSepsis

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