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The role of the orbitofrontal cortex in exercise addiction and exercise motivation: A brain imaging study based on
Feifei Zhang1, Hongsheng Xie2, Song Wang3
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China; Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China.
Background:
Excessive exercise may also lead to exercise addiction (EXA), which is harmful to people's physical and mental health. Behavioral and neuroimaging studies have demonstrated that addictive disorders are essentially motivational problems. However, little is known about the neuropsychological mechanism of EXA and the effects of motivation on EXA.
Methods:
We investigated 130 regularly exercised participants with EXA symptoms to explore the neurobiological basis of EXA and its association with motivation. The correlation between EXA and gray matter volume (GMV) was evaluated by whole-brain regression analysis based on voxel-based morphometry. Then, regional brain function was extracted and the relationship between brain structure-function-EXA was analyzed. Finally, mediation analysis was performed to further detect the relationship between the brain, motivation, and EXA.
Results:
Whole-brain correlation analyses showed that the GMV of the right orbitofrontal cortex (OFC) was negatively correlated with EXA. The function of the right OFC played an indirect role in EXA and affected EXA via the GMV of the OFC. Importantly, the GMV of the right OFC played a mediating role in the relationship between ability motivation and EXA. These results remain significant even when adjusting for sex, age, body mass index, family socioeconomic status, general intelligence, total intracranial volume, and head motion.
Limitation:
The results should be interpreted carefully because only the people with EXA symptoms were included.
Conclusion:
This study provided evidence for the underlying neuropsychological mechanism of the important role of the right OFC in EXA and revealed that there may be a decrease in executive control function in EXA.
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