Related Experiment Video
Updated: Aug 19, 2026

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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
[Effect of naloxone on hypoalgesia in rats exposed to prolonged immobilization stress]
Biulleten' Eksperimental'Noi Biologii I Meditsiny
|September 1, 1987
Abstract:
Significant hypoalgesia (tail-flick reflex at 60 degrees C) was observed in rats during the whole period of 24-hour immobilization in cramped cages, as compared to food-and-water deprived and control animals. This hypoalgesia was not antagonized by naloxone (1 mg/kg), however, the animals periodically receiving the drug during immobilization revealed aggressiveness and significant hypoalgesia after immobilization was discontinued (30-120 min observation).

