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Updated: Aug 14, 2025

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
Published on: May 26, 2011
Singlet Oxygen Responsive Molecular Receptor to Modulate Atropisomerism and Cation Binding
Quentin Bouteille1, Dorian Sonet1, Marc Hennebelle1
1Institut des Sciences Moléculaires UMR CNRS 5255, Université de Bordeaux, 351 cours de la Libération, 33405, Talence, France.
Abstract:
In switchable molecular recognition, 1 O2 stimulus responsive receptors offer a unique structural change that is rarely exploited. The employed [4+2] reaction between 1 O2 and anthracene derivatives is quantitative, reversible and easily implemented. To evaluate the full potential of this new stimulus, a non-macrocyclic anthracene-based host was designed for the modular binding of cations. The structural investigation showed that 1 O2 controlled the atropisomerism in an on/off fashion within the pair of hosts. The binding studies revealed higher association constants for the endoperoxide receptor compared to the parent anthracene, due to a more favoured preorganization of the recognition site. The fatigue of the 1 O2 switchable hosts and their complexes was monitored over five cycles of cycloaddition/cycloreversion.
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