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A Protocol for Analyzing Hepatitis C Virus Replication
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Management of Hepatitis C in Children - A New Paradigm

Ujjal Poddar1, D V Umesh Reddy2

  • 1Department of Pediatric Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh. Correspondence to: Dr Ujjal Poddar, Professor and Head, Department of Pediatric Gastroenterology, SGPGIMS, Raebareli Road, Lucknow 226 014, Uttar Pradesh. ujjalpoddar@hotmail.com.

Indian Pediatrics
|January 14, 2023
PubMed

Insights

Direct-acting antivirals (DAAs) have revolutionized hepatitis C (HCV) treatment in children, offering high efficacy and safety. Current DAA regimens simplify management for pediatric HCV infection, marking a significant advancement.

Area of Science:

  • Pediatric Hepatology
  • Virology
  • Pharmacotherapy

Background:

  • Hepatitis C virus (HCV) infection in children historically presented treatment challenges with interferon-based regimens.
  • Previous treatments for pediatric HCV infection showed limited efficacy (58% SVR) and significant side effects (52%).

Approach:

  • A literature search was conducted on PubMed, focusing on pediatric HCV (ages 0-18) treatment options.
  • The review analyzes the evolution of HCV management from older therapies to modern direct-acting antivirals (DAAs).

Key Points:

  • Direct-acting antivirals (DAAs) demonstrate high efficacy (92%-100% SVR12) and excellent safety profiles in children over three years old.
  • DAA regimens represent the current standard of care for pediatric hepatitis C infection.
  • Treatment simplification is a key outcome of DAA availability for pediatric HCV.

Conclusions:

  • DAA therapy has transformed pediatric HCV management, making treatment simpler and more effective.
  • Eliminating HCV in children requires continued DAA accessibility, public awareness, and improved screening strategies.
Abstract

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