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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

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Published on: January 24, 2025

Bioresponsive Immunotherapeutic Materials.

Jinpeng Han¹, Tao Sheng¹, Yuqi Zhang^1,2

¹Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.

Advanced Materials (Deerfield Beach, Fla.)

|January 14, 2023

Summary

Bioresponsive materials integrate with immunoactive agents to control immune responses for improved immunotherapies. This strategy enhances treatment efficacy and reduces side effects by enabling targeted, on-demand agent release.

Keywords:

autoimmune diseases bioresponsive materials cancer immunotherapy drug delivery vaccines

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Area of Science:

Biomaterials Science
Immunology
Drug Delivery Systems

Background:

Immune system dysfunction is linked to diseases like cancer, infections, and autoimmune disorders.
Targeted manipulation of immune responses is crucial for effective immunotherapy.
Current immunotherapies face challenges with efficacy and side effects due to systemic administration.

Purpose of the Study:

To review the design principles of bioresponsive materials for immunotherapy.
To discuss the role of controlled release of immunoactive agents in modulating immune cells.
To explore challenges and future directions for clinical translation of these materials.

Main Methods:

Integration of "smart" bioresponsive materials with various immunoactive agents (small molecules, biomacromolecules, cells).
On-demand release of agents at targeted sites.
Review of design principles and functional roles in immune cell manipulation.

Main Results:

Bioresponsive materials enable controlled, localized delivery of immunoactive agents.
This approach facilitates targeted recruitment, housing, and manipulation of immune cells.
Potential to enhance immunotherapeutic efficacy while minimizing toxicity and off-target effects.

Conclusions:

Bioresponsive immunotherapeutic materials offer a promising strategy for advanced therapies.
Controlled release is key to optimizing immune cell-based therapeutic outcomes.
Further research is needed to address clinical translation challenges.