Related Experiment Video
Updated: Aug 14, 2025
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
How do territorial characteristics affect spatial inequalities in the risk of coronary heart disease?
Delphine Brousmiche1, Caroline Lanier2, Damien Cuny3
1Univ. Lille, Univ. Artois, IMT Lille Douai, JUNIA, ULR 4515 - LGCgE, Laboratoire de Génie Civil et Géo-Environnement, F-59000 Lille, France; Association pour la Prévention de la Pollution Atmosphérique, F-59120 Loos, France.
Insights
This study identified three distinct territorial profiles linked to coronary heart disease (CHD) incidence. Some areas showed favorable conditions, while others, marked by deprivation or varied factors, had higher CHD rates, informing public health strategies.
Area of Science:
- Environmental Health
- Cardiology
- Public Health Policy
Background:
- Cardiovascular diseases (CVDs) are a leading global cause of death, with coronary heart diseases (CHDs) being most prevalent.
- CHD etiology is multifactorial, influenced by individual, behavioral, and territorial determinants.
- Assessing territorial characteristics is crucial for understanding CHD incidence.
Purpose of the Study:
- To establish complex territorial profiles in a densely populated, high-pollution area in Northern France.
- To identify determinants with beneficial or deleterious effects on cardiovascular health.
- To link standardized incidence rates of CHD to distinct territorial profiles.
Main Methods:
- Utilized 44 variables across economic, social, health, environmental, and service dimensions.
- Described multidimensional characteristics impacting cardiovascular health.
- Characterized territorial profiles using age- and gender-adjusted standardized incidence rates (SIR) for CHD.
Main Results:
- Three distinct territorial profiles for CHD incidence were identified.
- Profile 1 exhibited a favorable SIR (0.895) with beneficial territorial conditions.
- Profiles 2 (SIR 1.225) and 3 (SIR 1.119) showed higher CHD incidence, with dissimilar characteristics like deprivation, vegetation, pollution, and population privilege.
Conclusions:
- The methodology effectively characterized multidimensional determinants of cardiovascular health.
- Identified factors with negative and positive impacts on cardiovascular health.
- Provides a diagnostic tool for implementing contextualized public health policies to prevent CHD.
Background:
Cardiovascular diseases remain the leading cause of death and disabilities worldwide, with coronary heart diseases being the most frequently diagnosed. Their multifactorial etiology involves individual, behavioral and territorial determinants, and thus requires the implementation of multidimensional approaches to assess links between territorial characteristics and the incidence of coronary heart diseases.
Context And Objectives:
This study was carried out in a densely populated area located in the north of France with multiple sources of pollutants. The aim of this research was therefore to establish complex territorial profiles that have been characterized by the standardized incidence, thereby identifying the influences of determinants that can be related to a beneficial or a deleterious effect on cardiovascular health.
Methods:
Forty-four variables related to economic, social, health, environment and services dimensions with an established or suspected impact on cardiovascular health were used to describe the multidimensional characteristics involved in cardiovascular health.
Results:
Three complex territorial profiles have been highlighted and characterized by the standardized incidence rate (SIR) of coronary heart diseases after adjustment for age and gender. Profile 1 was characterized by an SIR of 0.895 (sd: 0.143) and a higher number of determinants that revealed favorable territorial conditions. Profiles 2 and 3 were characterized by SIRs of respectively 1.225 (sd: 0.242) and 1.119 (sd: 0.273). Territorial characteristics among these profiles of over-incidence were nevertheless dissimilar. Profile 2 revealed higher deprivation, lower vegetation and lower atmospheric pollution, while profile 3 displayed a rather privileged population with contrasted territorial conditions.
Conclusion:
This methodology permitted the characterization of the multidimensional determinants involved in cardiovascular health, whether they have a negative or a positive impact, and could provide stakeholders with a diagnostic tool to implement contextualized public health policies to prevent coronary heart diseases.
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
01:26Coronary Artery Disease IV: Preventive Measures
01:26Coronary Artery Disease II: Pathophysiology
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
01:30Coronary Artery Disease III: Clinical Manifestations
01:17Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...