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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
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Bioinspired multifunctional injectable hydrogel for hemostasis and infected wound management
Wen Fang1, Ling Yang2, Yihao Chen3
1MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Acta Biomaterialia
|January 14, 2023
Summary
A new injectable hydrogel, CQCS@gel, effectively stops bleeding and fights bacterial infections in wounds. This bioinspired material promotes healing by aiding collagen production and tissue regeneration, offering a promising solution for wound management.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing
Background:
- Routine wound management struggles with rebleeding and infection, limiting conventional dressings.
- Injectable hydrogels offer multifunctional wound healing but integrating diverse properties remains challenging.
- Existing treatments lack advanced functionalities for promoting rapid and effective wound recovery.
Purpose of the Study:
- To develop a novel, bioinspired, multifunctional injectable hydrogel for hemostasis and infected wound healing.
- To create a simple, two-component hydrogel system with enhanced properties for clinical applications.
- To evaluate the hemostatic and wound healing capabilities of the developed hydrogel in vivo.
Main Methods:
- Synthesized a hydrogel (CQCS@gel) from catechol-functionalized quaternized chitosan (CQCS) and dibenzaldehyde-terminated poly(ethylene glycol) (DB-PEG2000).
- Assessed in vitro properties including tissue adhesion, antibacterial activity, antioxidant capacity, self-healing, and pH-responsiveness.
- Evaluated in vivo hemostasis on liver and carotid wounds and chronic wound healing in MRSA-infected cutaneous models.
Main Results:
- CQCS@gel demonstrated rapid gelation, strong tissue adhesion, effective antibacterial action, antioxidant properties, self-healing, and pH-responsiveness.
- Achieved rapid hemostasis in acute tissue injuries (liver, carotid wounds).
- Significantly accelerated chronic wound healing in infected models by promoting collagen deposition, hair follicle regeneration, and angiogenesis.
Conclusions:
- The developed CQCS@gel is a biocompatible, multifunctional injectable hydrogel with potential as a universal wound dressing.
- The hydrogel effectively addresses challenges in hemostasis and infected wound management.
- This innovative material offers a low-cost, easily accessible solution for advanced wound care applications.
