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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Related Experiment Video

Updated: Aug 14, 2025

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

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Platelet Transfusion After Cardiac Surgery.

Calvin M Fletcher1, Jake V Hinton2, Zhongyue Xing2

  • 1Department of Anaesthesiology and Perioperative Medicine, The Alfred Hospital, Melbourne, Victoria, Australia.

Journal of Cardiothoracic and Vascular Anesthesia
|January 14, 2023
PubMed
Summary

Platelet transfusions in cardiac surgery patients did not increase hospital mortality. However, they were linked to fewer infections and shorter intensive care unit (ICU) and hospital stays.

Keywords:
CABG, hemorrhagecardiac surgeryperioperative medicineplateletstransfusion

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Area of Science:

  • Cardiovascular Surgery
  • Transfusion Medicine
  • Critical Care Medicine

Background:

  • Platelet transfusion is common in cardiac surgery.
  • Its association with clinical outcomes requires further investigation.

Purpose of the Study:

  • To examine the independent association of platelet transfusion with hospital mortality and clinical outcomes in adult cardiac surgery patients.

Main Methods:

  • Retrospective, propensity score-matched cohort study.
  • Included adult patients undergoing coronary artery bypass graft and/or valvular surgery.
  • Analyzed data from 2001-2019 using the MIMIC III and IV databases.

Main Results:

  • 1,621 of 12,043 patients received platelet transfusions.
  • No association found between platelet transfusion and in-hospital mortality (OR: 1.28; 99% CI: 0.49-3.35).
  • Associated with decreased odds of suspected infection (OR: 0.70; 99% CI: 0.50-0.97) and shorter ICU/hospital stays.

Conclusions:

  • Perioperative platelet transfusion in cardiac surgery is not linked to increased hospital mortality.
  • Platelet transfusion may reduce the risk of suspected infections.
  • Associated with reduced length of stay in the ICU and hospital.