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Adenovirus infection is a risk factor for recurrent intussusception in pediatric patients

Wen-Yu Tseng1, Hsun-Chin Chao2, Chien-Chang Chen2

  • 1Division of Pediatric Gastroenterology, Department of Pediatrics, Chang Gung Children's Medical Center, Chang Gung Memorial Hospital, 5 Fu-Hsing Street, Guishan District, Taoyuan City, 33305, Taiwan.

Pediatrics and Neonatology
|January 14, 2023
PubMed

Insights

Pediatric intussusception linked to adenovirus infection involves longer fever duration and increased recurrence rates. Patients with suspected adenovirus intussusception require extended observation before discharge.

Area of Science:

  • Pediatric Gastroenterology
  • Viral Pathogenesis
  • Clinical Epidemiology

Background:

  • Human adenoviruses are primary pathogens in pediatric intussusception.
  • Clinical features of adenovirus-associated pediatric intussusception remain poorly understood.

Approach:

  • Retrospective review of medical records for pediatric patients (≤18 years) treated for intussusception from 2014-2020.
  • Comparison of demographic and clinical characteristics between patients with and without adenovirus infections.
  • Evaluation of intussusception recurrence rates and management strategies.

Key Points:

  • Adenovirus-infected patients had significantly longer febrile durations (4.3 vs. 3.3 days).
  • Higher recurrence rates observed in the adenovirus group (48.1%) compared to controls (13.8%).
  • Non-enteric adenoviruses were predominant (85.2%) in the infected group.

Conclusions:

  • Adenovirus-related intussusception is characterized by prolonged fever and elevated recurrence risk.
  • Extended observation is recommended for pediatric patients with suspected adenovirus intussusception.
Abstract

Keywords:
adenoviruschildrenrecurrent intussusceptionrisk factor

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