Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosurgery01:30

Psychosurgery

92
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
92
Brain Imaging01:14

Brain Imaging

277
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
277

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Negative Contextual Valence Unmasks Altered Counterfactual Decision-Making in Major Depressive Disorder.

medRxiv : the preprint server for health sciences·2026
Same author

Opposing effects of slow and fast theta synchrony on working memory in the human hippocampal-orbitofrontal network.

bioRxiv : the preprint server for biology·2026
Same author

Globus pallidus externus (GPe) alpha band activity decreases after deep brain stimulation in clinically responsive obsessive-compulsive disorder patients.

medRxiv : the preprint server for health sciences·2026
Same author

Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children.

The Cochrane database of systematic reviews·2026
Same author

Sustained activity of human substantia nigra neurons reflect prior rewards.

iScience·2026
Same author

Reduced Affiliative Behavior in Autism Reflects Greater Dependence on Perceived Similarity.

Research square·2026
Same journal

Impact of Transcranial Direct Current Stimulation-Induced Electric Fields on Slowing Cognitive Decline in Older Adults With Mild Cognitive Impairment or Remitted Major Depressive Disorder: An Analysis of the PACt-MD Randomized Clinical Trial.

Biological psychiatry·2026
Same journal

Remembering Jon-Kar Zubieta, M.D., Ph.D.

Biological psychiatry·2026
Same journal

Kappa opioid receptor availability in borderline personality disorder: An in-vivo investigation with [<sup>11</sup>C]EKAP PET imaging.

Biological psychiatry·2026
Same journal

From Satiety to Substance Use: Neural Mechanisms of GLP-1 Signaling in Appetite and Reward.

Biological psychiatry·2026
Same journal

Distinct and Shared Molecular Mechanisms Underlie Morphological-Functional Overcoupling and Undercoupling in Major Depressive Disorder.

Biological psychiatry·2026
Same journal

Dynamic Brain States With Cannabis Intoxication: Beyond "More Is Better" in Interpreting Brain Connectivity.

Biological psychiatry·2026
See all related articles

Related Experiment Video

Updated: Aug 14, 2025

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
08:25

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

10.8K

Invasive Computational Psychiatry.

Ignacio Saez1, Xiaosi Gu2

  • 1Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.

Biological Psychiatry
|January 14, 2023
PubMed
Summary
This summary is machine-generated.

Computational psychiatry needs advancement. Combining computational psychiatry with invasive neuroscience offers a new direction, invasive computational psychiatry, for deeper brain insights and therapeutic potential.

Keywords:
Algorithmic targetingComputational psychiatryDBSECoGIntracranial neurosciencesEEG

More Related Videos

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

45.7K
A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.4K

Related Experiment Videos

Last Updated: Aug 14, 2025

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans
08:25

Combined Invasive Subcortical and Non-invasive Surface Neurophysiological Recordings for the Assessment of Cognitive and Emotional Functions in Humans

Published on: May 19, 2016

10.8K
Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

45.7K
A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.4K

Area of Science:

  • Neuroscience
  • Computational Psychiatry
  • Invasive Electrophysiology

Background:

  • Computational psychiatry aims to understand psychiatric disorders but progress has been stagnant.
  • Invasive neuroscience techniques offer precise measurement and modulation of brain activity.
  • Recent advances in intracranial neuroscience have significantly benefited brain understanding.

Purpose of the Study:

  • To review progress and drawbacks in computational psychiatry and invasive electrophysiology.
  • To propose a novel, combined approach: invasive computational psychiatry.
  • To highlight the potential of this integrated field for advancing mechanistic understanding and therapeutic interventions.

Main Methods:

  • Review of computational psychiatry literature.
  • Analysis of invasive electrophysiology techniques (stereotactic electroencephalography, electrocorticography, deep brain stimulation).
  • Case study of depression to illustrate the combined approach's success.

Main Results:

  • Invasive computational psychiatry offers spatiotemporally precise neural activity depiction.
  • Algorithmic targeting enables direct modulation of brain states for causal and therapeutic insights.
  • Initial success demonstrated in applying this combined approach to depression.

Conclusions:

  • Invasive computational psychiatry represents a promising new direction for understanding and treating psychiatric disorders.
  • This integrated approach enhances mechanistic understanding of neural computations underlying mental states.
  • Future directions and ethical considerations for this emerging field are outlined.