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The Integrator complex desensitizes cellular response to TGF-β/BMP signaling

Sen Liu1, Gyeong Hun Baeg2, Ying Yang1

  • 1Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore 117604, Singapore.

Cell Reports
|January 15, 2023
PubMed
Summary

Integrator restricts Decapentaplegic (Dpp)/Bone Morphogenetic Protein (BMP) signaling in the cytoplasm, promoting germline differentiation in Drosophila. This complex also desensitizes cellular responses to Dpp/BMP signaling, suggesting a conserved role in metazoans.

Keywords:
CP: Cell biologyCP: Stem cell researchDpp/BMP signalingDrosophilaE3 ubiquitin ligaseI-SmadIntegratorSmurfTGF-β/BMP signalinggermline stem cellsstem cell nichestem cells

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